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- Title
Thyroid effects of tyrosine kinase inhibitors.
- Authors
Illouz, Frédéric; Braun, Doreen; Briet, Claire; Schweizer, Ulrich; Rodien, Patrice
- Abstract
Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hyperthyroidism. In this study, the various molecules implicated in thyroid dysfunctions are analysed and the latest data on physiopathological mechanisms are approached in order to propose a strategy of thyroid monitoring of patients on TKI therapy.
- Subjects
PROTEIN-tyrosine kinases; HYPOTHYROIDISM; HYPERTHYROIDISM; THYROTROPIN; ENDOCRINOLOGY; THERAPEUTICS
- Publication
European Journal of Endocrinology, 2014, Vol 171, Issue 3, pR91
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-14-0198