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- Title
Effect of macromolecular crowding on the rate of diffusion-limited enzymatic reaction.
- Authors
Agrawal, Manish; Santra, S. B.; Anand, Rajat; Swaminathan, Rajaram
- Abstract
The cytoplasm of a living cell is crowded with several macromolecules of different shapes and sizes. Molecular diffusion in such a medium becomes anomalous due to the presence of macromolecules and diffusivity is expected to decrease with increase in macromolecular crowding. Moreover, many cellular processes are dependent on molecular diffusion in the cell cytosol. The enzymatic reaction rate has been shown to be affected by the presence of such macromolecules. A simple numerical model is proposed here based on percolation and diffusion in disordered systems to study the effect of macromolecular crowding on the enzymatic reaction rates. The model qualitatively explains some of the experimental observations.
- Subjects
ENZYMATIC analysis; CYTOPLASM; ENZYME kinetics; PERCOLATION; MACROMOLECULES
- Publication
Pramana: Journal of Physics, 2008, Vol 70, Issue 8, p359
- ISSN
0304-4289
- Publication type
Article