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- Title
Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer.
- Authors
Wang, Fang; He, Wenzhuo; Jiang, Chang; Guo, Guifang; Ke, Bin; Dai, Qiangsheng; Long, Jianting; Xia, Liangping
- Abstract
<bold>Background: </bold>The modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). The systemic inflammation score (SIS) has been shown to be more informative than the mGPS in CRC. The albumin-NLR, composed of albumin and the NLR, can also be a candidate for a valuable inflammation score. However, about the utility of the mGPS, SIS, and albumin-NLR for CRC patients who have received radical resections remains unclear.<bold>Methods: </bold>This study enrolled 877 CRC patients, who underwent radical surgical resection between January 1, 2007 and December 31, 2014. The prognostic values of the mGPS, SIS, and albumin-NLR were compared by the Kaplan-Meier survival analysis, multivariate Cox regression modelling, and the time-dependent receiver operating characteristic curve analysis (ROC).<bold>Results: </bold>In the Kaplan-Meier analysis, all three inflammation scores were significantly associated with overall survival (OS) in the group including all the patients (mGPS, p = 0.016; SIS, p < 0.001; albumin-NLR, p = 0.007) and in the left-sided colon tumour subgroup (mGPS, p = 0.029; SIS p = 0.0013; albumin-NLR, p = 0.001). In the right-sided colon tumour subgroup, only the albumin-NLR was associated with OS (p = 0.048). The albumin-NLR was the only independent prognostic factor of the three scores for OS in the multivariate survival analysis.<bold>Conclusions: </bold>The albumin-NLR outperformed both the SIS and mGPS in predicting OS in CRC patients undergoing radical resection.
- Subjects
COLON tumors; INFLAMMATION; LYMPHOCYTES; NEUTROPHILS; PROGNOSIS; RECTUM tumors; RESEARCH funding; TUMOR classification; SEVERITY of illness index; RECEIVER operating characteristic curves; KAPLAN-Meier estimator; LEUKOCYTE count; GLASGOW Coma Scale; TUMOR grading
- Publication
BMC Cancer, 2018, Vol 18, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-018-4842-3