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- Title
New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts.
- Authors
Pagano, Aldo; Castelnuovo, Manuele; Tortelli, Federico; Ferrari, Roberto; Dieci, Giorgio; Cancedda, Ranieri
- Abstract
By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/ antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.
- Subjects
GENES; GENOMES; GENETICS; HUMAN gene mapping; HUMAN genome
- Publication
PLoS Genetics, 2007, Vol 3, Issue 2, p174
- ISSN
1553-7390
- Publication type
Article
- DOI
10.1371/journal.pgen.0030001