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- Title
The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation.
- Authors
Xiaoyu Zhang; Germann, Sophie; Blus, Bartlomiej J.; Khorasanizadeh, Sepideh; Gaudin, Valerie; Jacobsen, Steven E.
- Abstract
Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation (H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID-chip method, we found that the Arabidopsis thaliana chromodomain-containing protein LHP1 colocalizes with H3K27me3 genome-wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb.
- Subjects
PROTEINS; CHROMATIN; HISTONES; ARABIDOPSIS thaliana; GENE expression; GENETIC regulation
- Publication
Nature Structural & Molecular Biology, 2007, Vol 14, Issue 9, p869
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb1283