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- Title
Expression of Platelet-Derived Growth Factor-AA is Associated with Tumor Progression in Osteosarcoma.
- Authors
Sulzbacher, Irene; Birner, Peter; Trieb, Klemens; Träxler, Margit; Lang, Susanna; Chott, Andreas
- Abstract
Platelet-derived growth factors are secreted by mesenchymal cells. The homodimer platelet-derived growth factor-AA. especially stimulates bone cells through interaction with the platelet-derived growth factor-α receptor homodimer. In this study we wanted to determine the expression of the receptor and its ligand in human osteosarcomas and to correlate the expression of platelet-derived growth factor-AA and -α receptor with clinicopathological parameters. Fifty-seven osteosarcomas were immunohistochemically analyzed for expression of platelet-derived growth factor-AA and platelet-derived growth factor-α receptor. Spearman's correlation coefficient revealed a strong correlation between the expression of platelet-derived growth factor-AA and platelet-derived growth factor-α receptor (r = 0.867). No differences were observed relative to gender, age, tumor stage, tumor location, and response to neoadjuvant chemotherapy between high or low platelet-derived growth factor-AA and platelet-derived growth factor-α receptor expression. High platelet-derived growth factor-AA expression correlated with tumor progression in univariate analysis (P = .0415; log-rank test), whereas platelet-derived growth factor-α receptor expression showed a trend toward a shorter disease-free survival, which failed to reach significance (P = .0627, log-rank test). In multivariate analysis, platelet-derived growth factor-AA expression remained a significant independent predictor of tumor progression (P = .021, Cox regression). Immunohistochemical analysis of platelet-derived growth factor-AA expression in osteosarcoma may be a useful marker of prognosis and may be considered as a possible target for novel therapeutic strategies.
- Subjects
GROWTH factors; PLATELET-derived growth factor; BLOOD proteins; DRUG therapy; MULTIVARIATE analysis; PROGNOSIS; OSTEOSARCOMA
- Publication
Modern Pathology, 2003, Vol 16, Issue 1, p66
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1097/01.MP.0000043522.76788.0A