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- Title
A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome.
- Authors
He, Junli; Wang, Li; Liu, Junhong; Liu, Feng; Li, Xuliang
- Abstract
Purpose: To investigate the influence of the peroxisome proliferator activated receptor gamma (PPAR-γ) Pro12Ala polymorphism on the susceptibility of polycystic ovary syndrome (PCOS) and body mass index (BMI), fast insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) in PCOS patients. Methods: PubMed, EMBASE, MEDLINE and CENTRAL databases were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between Pro12Ala polymorphism and PCOS. Results: Seventeen eligible studies, including 2,149 patients and 2,124 controls were enrolled in this meta-analysis. Pro12Ala polymorphism was significantly associated with the susceptibility of PCOS (odds ratio [OR] 0.74, 95 % confidence interval [CI] [0.61, 0.90] for allele; OR 0.70, 95 % CI [0.57, 0.86] for genotype). In the European subgroup of PCOS, the X/Ala genotype was associated with lower BMI (mean difference [MD] −1.08, 95 % CI [−2.08, −0.09]) and fast insulin levels (MD −19.82, 95 % CI [−34.07, −5.58]). However, this polymorphism did not display an impact on HOMA-IR in PCOS patients. Conclusions: Ala variant would decrease the risk of PCOS and result in lower BMI and fast insulin levels in a European population, but had no impact on HOMA-IR in PCOS patients. Further studies are required to elucidate these associations more clear.
- Subjects
GENETIC polymorphisms; POLYCYSTIC ovary syndrome; META-analysis; PEROXISOME proliferator-activated receptors; BODY mass index; INSULIN; CONFIDENCE intervals
- Publication
Journal of Assisted Reproduction & Genetics, 2012, Vol 29, Issue 7, p669
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-012-9772-4