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- Title
TCF7L2 polymorphism and cognitive test performance in cardiovascular disease.
- Authors
KEARY, Therese Anne; GUNSTAD, John; BENITEZ, Andreana; SPITZNAGEL, Mary Beth; MCCAFFERY, Jeanne; MCGEARY, John E.; POPPAS, Athena; PAUL, Robert H.; SWEET, Lawrence H.; COHEN, Ronald A.
- Abstract
Aims: The present study examines cognitive function among transcription factor 7-like 2 (TCF7L2) genotype groups in a sample of older adults with cardiovascular disease. Methods: We recruited 111 older adults with diagnosed cardiovascular disease from outpatient cardiology clinics. Neuropsychological tests assessed the following domains of cognitive functioning: global function, attention/executive/psychomotor speed, learning and memory, visuospatial/construction, motor, and language. Genotyping of TCF7L2 single nucleotide polymorphism rs7903146 was conducted to determine membership in the TT, CT, or CC genotype groups. Results: Controlling for diabetes status, participants with the TT genotype of TCF7L2 ( n= 12) performed worse on tests of attention/executive function/processing speed than those with the CC ( n= 46) and CT ( n= 53) genotypes, despite no between-group differences in demographic or medical variables. Conclusions: Older cardiovascular disease patients with the TCF7L2 TT genotype performed worse on tests of attention/executive/ psychomotor speed than CC and CT genotype carriers. Further work using neuroimaging and glucose tolerance indices is needed to clarify underlying mechanisms.
- Subjects
ANALYSIS of variance; CARDIOVASCULAR diseases; CHI-squared test; COGNITION in old age; GENES; GENETIC polymorphisms; NEUROPSYCHOLOGICAL tests; MEDICAL screening; SCALES (Weighing instruments); DATA analysis software
- Publication
Psychogeriatrics, 2012, Vol 12, Issue 2, p93
- ISSN
1346-3500
- Publication type
Article
- DOI
10.1111/j.1479-8301.2011.00398.x