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- Title
Dual‐drug release from chitin‐based core–shell microspheres fabricated by coaxial electrospray.
- Authors
Shang, Yu; Ding, Fuyuan; Liu, Jian; Xiao, Ling; Deng, Hongbing; Du, Yumin; Shi, Xiaowen
- Abstract
Abstract: Polymeric core–shell microspheres have been widely applied in dual‐drug release system for their convenience to treat diseases through multiple therapies. In this contribution, acrylamide‐modified chitin (AMC)/chitosan (CS) core–shell microspheres were prepared by a coaxial electrospray method under mild conditions. The dimension of the microspheres and thickness of the layer can be delicately controlled by changing the feed rate of spray solutions and the applied voltage. The core–shell structure of the microspheres was characterized by Fourier transform infrared spectra (FT‐IR), scanning electron microscope (SEM), and stereo fluorescence microscope. To investigate the dual‐drug release behavior of the core–shell microspheres, small molecular FITC‐dextran and macromolecular dextran blue 2000 were chosen as model drugs. The release rate of small molecular FITC‐dextran was higher than macromolecular dextran blue 2000 regardless of the location of FITC‐dextran in the microspheres. The biocompatibility, biodegradability, and dual‐drug release behavior of the core–shell microspheres endow it with potential applications in combination therapies.
- Subjects
COAXIAL cables; MICROSPHERES; ACRYLAMIDE analysis; FOURIER transform infrared spectroscopy; FLUORESCENCE
- Publication
Advances in Polymer Technology, 2018, Vol 37, Issue 5, p1366
- ISSN
0730-6679
- Publication type
Article
- DOI
10.1002/adv.21795