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- Title
EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disorders
- Authors
Veloza, Luis; Tsai, Chun-Yi; Bisig, Bettina; Pantet, Olivier; Alberio, Lorenzo; Sempoux, Christine; Cavassini, Matthias; de Leval, Laurence
- Abstract
Intravascular large B-cell lymphoma is a rare and aggressive EBV-negative large B-cell lymphoma with a dismal outcome. Here, we describe the case of a 76-year-old HIV-positive patient with an acute presentation of systemic symptoms and rapidly fatal outcome. Autopsy revealed a disseminated large B-cell lymphoma with an intravascular distribution involving the liver, lymph nodes, spleen, and bone marrow and associated to fibrin thrombi in hepatic capillary haemangiomas. The neoplastic B cells (CD79a + / − , CD20 + / − , CD30 + , MUM1 + , PD-L1 +) showed a Hodgkin and Reed-Sternberg-like morphology and were EBV-positive with a latency type II (LMP1 + , EBNA2-). Haemophagocytosis was documented in the bone marrow and lymph nodes. This case illustrates the diagnostic challenges of large B-cell lymphoma with intravascular presentation. We found only five other cases of EBV-positive large B-cell lymphoma with an intravascular presentation in the literature, three of which had an underlying immunodeficiency adding to the broad spectrum of EBV-associated lymphoma in the setting of immunosuppression.
- Subjects
B cell lymphoma; HIV infections; IMMUNOSUPPRESSION; AUTOPSY; LYMPH nodes
- Publication
Virchows Archiv: European Journal of Pathology, 2022, Vol 480, Issue 3, p699
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-021-03142-1