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- Title
Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater.
- Authors
Daniel Baumhoer; Inti Zlobec; Luigi Tornillo; Wolfgang Dietmaier; Peter Wuensch; Arndt Hartmann; Fausto Sessa; Petra Ruemmele; Luigi Terracciano
- Abstract
Abstract Carcinomas of the ampulla of Vater are rare and assumed to generally arise from preexisting adenomas (adenoma–carcinoma sequence). Histologically, distinct subtypes can be distinguished that were shown to differ significantly in terms of clinical outcome. Since pathologists usually receive bioptic tissue samples of ampullary tumors obtained during endoscopy, accurate classification of carcinoma subtypes can sometimes be difficult on morphological criteria alone. We therefore performed immunohistochemistry using a panel of established marker proteins (CK7, CK20, p21, p27, ESA, bax, and ephrin-B2) on 175 carcinoma, 111 adenoma, and 152 normal mucosa specimens of the ampulla of Vater and identified distinct immunoprofiles for every carcinoma subtype. Fluorescence in situ hybridization analyses of therapeutic target genes (c-myc, EGFR1, CCND1, HER2) found CCND1 to represent the most frequently amplified gene in our series (7.5%).
- Subjects
PATHOLOGY; ONCOLOGY; CYSTS (Pathology); ADENOMA
- Publication
Virchows Archiv: European Journal of Pathology, 2008, Vol 453, Issue 6, p579
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-008-0669-7