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- Title
Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization.
- Authors
Luoqin Yu; Jiqiang Kang; Jinata, Chandra; Xie Wang; Xiaoming Wei; Kin Tak Chan; Lee, Nikki P.; Wong, Kenneth K. Y.
- Abstract
A tri-band spectroscopic optical coherence tomography (SOCT) system has been implemented for visualization of lipid and blood vessel distribution. The tri-band swept source, which covers output spectrum in 1.3, 1.5, and 1.6 μmwavelength windows, is based on a dual-band Fourier domain mode-locked laser and a fiber optical parametric amplifier. This tri-band SOCT can further differentiate materials, e.g., lipid and artery, qualitatively by contrasting attenuation coefficients difference within any two of these bands. Furthermore, ex vivo imaging of both porcine artery with artificial lipid plaque phantom and mice with coronary artery disease were demonstrated to showcase the capability of our SOCT.
- Subjects
OPTICAL coherence tomography; OPTICAL parametric amplifiers; SPECTROMETRY; BLOOD vessels; CORONARY disease
- Publication
Journal of Biomedical Optics, 2015, Vol 20, Issue 12, p1
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.JBO.20.12.126006