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- Title
Non-invasive assessment of selective 5-HT<sub>1B/1D</sub>-receptor agonist-induced peripheral vascular effects in humans: comparison of different techniques.
- Authors
Vanmolkot, F. H.; de Hoon, J. N.; Barrington, P.; Peck, R. W.; Dallow, N. S.; Williams, P. M.; McColm, J.
- Abstract
Objective. To compare the sensitivity of three non-invasive techniques for detecting serotonin (5-HT)1B/1D-receptor agonist-induced peripheral vascular effects in humans: the measurement of (1) systolic (SBP) and diastolic (DBP) blood pressures, (2) dorsal hand vein (DHV) diameter and (3) toe–arm systolic blood pressure gradient (ΔSBPtoe–arm). Methods. A double-blind, placebo-controlled, three-way, cross-over study was performed in 12 healthy male volunteers. According to a randomly assigned allocation schedule, subjects were administered sumatriptan 3 mg, sumatriptan 6 mg or placebo subcutaneously. Measurements were performed at baseline, every 5 min for 30 min and at 40 min and 60 min after drug administration. SBP and DBP were recorded using a semi-automated oscillometric device. DHV diameter was measured using a linear variable differential transformer. ΔSBPtoe–arm was calculated after measuring toe and arm SBP with a strain-gauge technique. Sensitivity was evaluated with responsiveness statistics. Results. Based on weighted mean and compared with placebo, sumatriptan 3 mg and 6 mg increased SBP by 3.3 mmHg (P=0.023) and 6.4 mmHg (P<0.001) and DBP by 5.0 mmHg (P=0.006) and 7.5 mmHg (P<0.001), respectively. Sumatriptan 3 mg and 6 mg decreased DHV diameter by 36% (P=0.015) and 40% (P=0.005), respectively. ΔSBPtoe–arm did not change. Peak changes were observed within 10–15 min after drug administration. The rank order of responsiveness was: BP > DHV diameter > ΔSBPtoe–arm. Conclusions. Clinically relevant doses of subcutaneous sumatriptan increased blood pressure and decreased DHV diameter without affecting ΔSBPtoe–arm. The increase in blood pressure appeared to be dose dependent. Compared with DHV diameter and ΔSBPtoe–arm, blood pressure measurement appeared to be the most sensitive technique for detecting selective 5-HT1B/1D-receptor agonist-induced peripheral vascular effects in humans.
- Subjects
SEROTONIN; PERIPHERAL vascular diseases; BLOOD pressure; PLACEBOS; SUMATRIPTAN
- Publication
European Journal of Clinical Pharmacology, 2002, Vol 58, Issue 5, p303
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-002-0482-1