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- Title
Treatment of Hepatocellular Carcinoma Using Internally Cooled Electrodes.
- Authors
Cua, Ian Homer Y.; Chen-Chun Lin; Chun-Jung Lin; Wei-Ting Chen; Chao-Wei Hsu; Yi-Cheng Chen; Wong, Stephen N.; Shi-Ming Lin
- Abstract
Objectives: To compare the effectiveness of modified automated and manual pulsed radiofrequency (RF) algorithms using internally cooled electrodes for hepatocellular carcinoma (HCC). Methods: Seventy-seven treatment-naive cirrhotic patients with 102 HCC (≤4 cm) underwent 109 sessions of ultrasound-guided percutaneous RF ablation using a 17-gauge, 20-cm-long, single internally cooled electrode. Patients were assigned alternatively: 40 patients to the modified automated algorithm group and 37 patients to the manual algorithm group. The mean tumor diameters were 2.34 ± 0.9 and 2.25 ± 0.7 cm in the automated and manual groups, respectively (p = 0.56). Primary technique effectiveness and local tumor progression were compared between the two groups. Results: More overlapping ablations (n = 112) were required in the manual than in the automated group (n = 82) to achieve similar primary technique effectiveness rates of 96.1 and 94.1%, respectively. After a mean follow-up period of 26.7 ± 1.1 months, the local tumor progression rates at 12 and 18 months were 4 and 20% in the manual group and 12 and 24% in the modified automated group (p = 0.3). Only tumors >3 cm were independently associated with local tumor progression (odds ratio 1.25; 95% CI 1.06–2.34, p = 0.03). Conclusions: The manual algorithm requires more overlapping ablations and treatment sessions in order to achieve similar primary technique effectiveness and local tumor progression rates compared with the modified automated algorithm. Copyright © 2007 S. Karger AG, Basel
- Subjects
LIVER cancer; ELECTRODES; RADIO frequency therapy; CIRRHOSIS of the liver; ALGORITHMS; THERAPEUTICS
- Publication
Oncology, 2007, Vol 72, p76
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000111711