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- Title
Successful transplantation of a donor kidney with diffuse proliferative lupus nephritis and crescents—a case report.
- Authors
Magoon, Sandeep; Zhou, Eric; Pullman, James; Greenstein, Stuart M.; Glicklich, Daniel G.
- Abstract
Pre-existing diffuse proliferative glomerulonephritis (DPGN) in a potential deceased kidney donor has been considered a contraindication for transplantation. We report a case of a patient who underwent a successful deceased donor renal transplantation from a donor with history of systemic lupus erythematosus (SLE) whose baseline biopsy revealed DPGN. Although the histology was relatively benign in the procurement kidney biopsy done by frozen section, the final light microscopy available after transplantation showed diffuse proliferative lupus nephritis, WHO class IV, with 44% crescents. The post-transplant course was complicated by delayed allograft function requiring haemodialysis for the first week. A repeat biopsy performed after 4 months of transplant showed resolution of the proliferative lesions in the glomeruli with disappearance of the crescents. At 5.5 years of follow-up, the patient’s creatinine has been stable at 2.0 mg/dL (176.8 μmol/L), but he has persistent proteinuria.
- Subjects
KIDNEY transplantation; ORGAN donors; LUPUS nephritis; GLOMERULONEPHRITIS; SYSTEMIC lupus erythematosus; RENAL biopsy; MICROSCOPY; HEMODIALYSIS; PROTEINURIA; PATIENTS
- Publication
Nephrology Dialysis Transplantation, 2010, Vol 25, Issue 12, p4109
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfq517