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- Title
Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression.
- Authors
Pahl, Madeleine V.; Gollapudi, Sastry; Sepassi, Lili; Gollapudi, Pavan; Elahimehr, Reza; Vaziri, Nosratola D.
- Abstract
Background. End-stage renal disease (ESRD) results in increased susceptibility to infections, impaired response to vaccination and diffuse B-cell lymphopenia. However, the precise nature and mechanism of ESRD-induced B-cell lymphopenia remains unclear. Therefore, we studied the distribution of major B-cell subsets, B-cell growth, differentiation and survival factors, IL-7 and BAFF, and their receptors in 21 haemodialysis patients and 21 controls.
- Subjects
B cells; LYMPHOCYTES; CHRONIC kidney failure; LYMPHOPENIA; LEUCOPENIA
- Publication
Nephrology Dialysis Transplantation, 2010, Vol 25, Issue 1, p205
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp397