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- Title
Application of physical methods of pharmacy to improve the properties of dosage forms.
- Authors
Zevak, E.; Ogienko, A.; Myz', S.; Yunoshev, A.; Kolesov, B.; Achkasov, A.; Il'dyakov, A.; Shinkorenko, M.; Krasnikov, A.; Kuchumov, B.; Ancharov, A.; Manakov, A.; Boldyreva, E.
- Abstract
It has been shown on the examples of paracetamol, ibuprofen, and salbutamol that the use of mixed water-organic solvents, which are capable of clathrate formation, enables one to obtain high-disperse drug powders that are weakly soluble in water via sublimation drying of frozen solutions. The prepared powders are applicable for direct compression to pellets, have a higher rate of passing into solution for drug compared to initial substances, and can be used to prepare the suspensions for children's preparations and dosage forms as freon-free aerosols for pulmonary administration.
- Subjects
PHARMACY; DOSAGE forms of drugs; SOLUTIONS (Pharmacy); AEROSOLS; ACETAMINOPHEN; IBUPROFEN
- Publication
Theoretical Foundations of Chemical Engineering, 2014, Vol 48, Issue 5, p722
- ISSN
0040-5795
- Publication type
Article
- DOI
10.1134/S0040579514050133