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- Title
Incidence of young‐onset dementia in Italy: The Brescia register study.
- Authors
Borroni, Barbara; Libri, Ilenia; Rota, Matteo; Binetti, Giuliano; Benussi, Luisa; Ghidoni, Roberta; Cotelli, Maria Sofia; Fostinelli, Silvia; Guerini, Fabio; Boffelli, Stefano; Magni, Eugenio; Pengo, Marta; Gennuso, Michele; Bianchi, Marta; Cossu, Beatrice; Palomba, Vincenzo; Crucitti, Andrea; Bianchetti, Angelo; Logroscino, Giancarlo; Padovani, Alessandro
- Abstract
INTRODUCTION: The goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young‐onset dementia [YOD]) and define the frequencies of young‐onset Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and dementia with Lewy bodies (DLB) in the general population. METHODS: The study was conducted from January 1, 2019 to December 31, 2019 in Brescia province (population: 1,268,455). During the study period, all new YOD cases (incident YOD) were counted, and all patients' records reviewed. The incidence was standardized to the Italian general population in 2019. RESULTS: A total of 29 YOD patients were diagnosed. The age‐sex standardized incidence rate was 4.58 (95% confidence interval, 3.07–6.58) per 100,000 person‐years. No difference in incidence rate between YOD due to AD or FTLD (P = 0.83) and between sexes (P = 0.81) was observed. YOD incidence increased with age, reaching its peak after 60 years. DISCUSSION: Presenting neurodegenerative YOD phenotypes encompasses both AD and FTLD. Improved knowledge on YOD epidemiology is essential to adequately plan and organize health services.
- Subjects
BRESCIA (Italy); ITALY; LEWY body dementia; ALZHEIMER'S disease; DEMENTIA; FRONTOTEMPORAL dementia; APOLIPOPROTEIN E4
- Publication
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2024, Vol 16, Issue 1, p1
- ISSN
2352-8729
- Publication type
Article
- DOI
10.1002/dad2.12544