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- Title
On the Role of CD4<sup>+</sup> T Cells in the CD8<sup>+</sup> T-Cell Response Elicited by Recombinant Adenovirus Vaccines.
- Authors
Teng Chih Yang; Millar, James; Groves, Timothy; Wenzhong Zhou; Grinshtein, Natalie; Parsons, Robin; Evelegh, Carole; Zhou Xing; Yonghong Wan; Bramson, Jonathan
- Abstract
We have investigated the role of CD4+ T cells in the development of the CD8+ T-cell response after immunization with recombinant adenovirus (rAd). In the absence of CD4+ T cells, the “unhelped” CD8+ T-cell population exhibited a reduction in primary expansion and long-term survival that appeared to be due to inadequate priming of naïve T cells. There were few functional or phenotypic differences between the helped and unhelped CD8+ T-cell populations with the exception of O-glycosylated CD43, a marker of effector cells, which was augmented on the unhelped CD8+ T-cell population. In some cases, the unhelped CD8+ T-cell population exhibited reduced ability to control virus infection; however, this appeared to be a function of the reduced frequency of antigen-specific CD8+ T cells. Most notably, the unhelped CD8+ T-cell population exhibited no defect in secondary expansion. These results provide insight into the role of CD4+ T cells during the primary CD8+ T-cell response generated by rAd vaccines and identify potential benefits and issues that must be considered when using adenovirus vaccines under conditions where CD4+ T-cell function may be limiting, such as vaccination of human immunodeficiency virus patients.Molecular Therapy (2007) 15 5, 997–1006. doi:10.1038/mt.sj.6300130
- Subjects
T cells; VIRUS diseases; CELLULAR immunity; GENETIC engineering; THERAPEUTICS; GENE therapy
- Publication
Molecular Therapy, 2007, Vol 15, Issue 5, p997
- ISSN
1525-0016
- Publication type
Article
- DOI
10.1038/sj.mt.6300130