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- Title
Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma.
- Authors
di Masi, Alessandra; Sessa, Rosario Luigi; Cerrato, Ylenia; Pastore, Gianni; Guantario, Barbara; Ambra, Roberto; Di Gioacchino, Michael; Sodo, Armida; Verri, Martina; Crucitti, Pierfilippo; Longo, Filippo; Naciu, Anda Mihaela; Palermo, Andrea; Taffon, Chiara; Acconcia, Filippo; Bianchi, Fabrizio; Ascenzi, Paolo; Ricci, Maria Antonietta; Crescenzi, Anna
- Abstract
FA Oxy, follicular thyroid adenoma oncocytic variant; FC, follicular thyroid carcinoma; FC Oxy, follicular thyroid carcinoma oncocytic variant; FV-PTC, follicular variant-papillary thyroid carcinoma; n.a., not available; PTC, papillary thyroid carcinoma; PTC Oxy, papillary thyroid carcinoma oncocytic variant; TI-RADS, Thyroid Imaging - Reporting and Data System. (B) Mean values of -carotene, -carotene, lutein, and lycopene concentrations (ng/g of thyroid tissue) quantified in the healthy and pathological lobes of the thyroids derived from four PTC patients (i.e., TIR22, TIR54, TIR77, and TIR94), together with seven unidentified peaks attributable to molecules with absorbances measured at 450 and 472 nm. Determination of Carotenoids Content in Healthy and PTC Thyroids by HPLC The presence of carotenoids in PTC patients was corroborated using the HPLC analyses of thyroids (Figure 1A). The patient eligibility criteria were as follows: (i) >=18 years old; (ii) one or more thyroid nodules with a medium-high ultrasound risk of malignancy (Thyroid Imaging - Reporting and Data System (TI-RADS) score >=3) [[14]]; (iii) at least one thyroid nodule with a fine needle aspiration (FNA) report categorized as indeterminate, suspicious, or malignant and warranting thyroid surgery according to clinical guidelines [[15]]; (iv) final histological diagnosis of PTC; and (v) willingness to provide material for RS and carotenoid analysis.
- Subjects
CAROTENOIDS; LYCOPENE; THYROID cancer; PAPILLARY carcinoma; RETINOID X receptors
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081463