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- Title
Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer.
- Authors
NGUYEN, Thanh Thi Ngoc; TRAN, Minh Thi Hong; NGUYEN, Vy Thi Lan; NGUYEN, Uyen Doan Phuong; NGUYEN, Giang Dien Thanh; HUYNH, Luan Huu; NGUYEN, Hue Thi
- Abstract
MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.
- Subjects
SINGLE nucleotide polymorphisms; MICRORNA; BREAST cancer; NUCLEOTIDE sequence; NON-coding RNA
- Publication
Turkish Journal of Biology, 2020, Vol 44, Issue 5, p284
- ISSN
1300-0152
- Publication type
Article
- DOI
10.3906/biy-2004-78