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- Title
Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells
- Authors
Liu, Jianhui; Zheng, Xuxu; Yin, Fei; Hu, Yinhe; Guo, Lixia; Deng, Xiaohong; Chen, Gang; Jiajia, Jing; Zhang, Heng
- Abstract
Abstract: The emerging data show that the insulinotrophic hormone glucagon-like peptide-1(GLP-1) and its agonist extendin-4 have neurotrophic function to inducing neuronal differentiation of PC12 cells and prevent neurons damage challenged by oxidative stress. Here, with the model of high throughput screen for GLP-1 receptor agonists, we screen and identify that geniposide is a novel agonist for GLP-1 receptor. Furthermore, geniposide induces the neuronal differentiation of PC12 cells with resulting neurites outgrowth; we also observe an increase in expression of growth-associated protein-43. U0126, a selective MEK inhibitor, prevents neurites out growth and phosphorylation of mitogen-activated kinase proteins in PC12 cells induced by geniposide. All these results show that activation of GLP-1 receptor by geniposide to induce the neuronal differentiation of PC12 cells involves in MAPK signaling cascade.
- Subjects
GLUCAGON-like peptide 1; NEUROTROPHIC functions; NERVOUS system; CELLS
- Publication
International Journal of Developmental Neuroscience, 2006, Vol 24, Issue 7, p419
- ISSN
0736-5748
- Publication type
Article
- DOI
10.1016/j.ijdevneu.2006.08.009