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- Title
Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway.
- Authors
Dai, Hui; DENg, Hou-Bo; Wang, Ya-Hong; Guo, Jia-Juan
- Abstract
The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, β-catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol.
- Subjects
RESVERATROL; GASTRIC diseases; WNT protein genetics; CATENINS; APOPTOSIS
- Publication
Oncology Letters, 2018, Vol 16, Issue 2, p1579
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2018.8772