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- Title
Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation.
- Authors
Pantazopoulos, Charalampos; Iacovidou, Nicoletta; Kouskouni, Evangelia; Pliatsika, Paraskevi; Papalois, Apostolos; Kaparos, Georgios; Barouxis, Dimitrios; Vasileiou, Panagiotis; Lelovas, Pavlos; Kotsilianou, Olympia; Pantazopoulos, Ioannis; Gkiokas, Georgios; Garosa, Clara; Faa, Gavino; Xanthos, Theodoros
- Abstract
Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10–15 weeks with average weight of 19±2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p=0.027). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p=0.001). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values’ p=0.049, 0.01, and 0.004, resp.). Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.
- Subjects
ACUTE kidney failure prevention; THERAPEUTICS; CARDIAC arrest; KIDNEY physiology; ACUTE kidney failure; ANIMAL experimentation; BIOLOGICAL models; CARRIER proteins; CARDIOPULMONARY resuscitation; CREATININE; ERYTHROPOIETIN; FISHER exact test; INTERLEUKINS; PLACEBOS; PROBABILITY theory; RESEARCH funding; SALT; STATISTICAL sampling; STATISTICS; SWINE; VENTRICULAR fibrillation; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; DISEASE risk factors
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/3567275