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- Title
Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System.
- Authors
Xu, Qing-Qing; Xu, Yi-Jun; Yang, Cong; Tang, Ying; Li, Lin; Cai, Hao-Bin; Hou, Bo-Nan; Chen, Hui-Fang; Wang, Qi; Shi, Xu-Guang; Zhang, Shi-Jie
- Abstract
Sodium Tanshinone IIA sulfonate (STS) is a derivative of Tanshinone IIA (Tan IIA). Tan IIA has been reported to possess neuroprotective effects against Alzheimer’s disease (AD). However, whether STS possesses effect on AD remains unclear. This study aims to estimate whether STS could protect against scopolamine- (SCOP-) induced learning and memory deficit in Kunming mice. Morris water maze results showed that oral administration of STS (10 mg/kg and 20 mg/kg) and Donepezil shortened escape latency, increased crossing times of the original position of the platform, and increased the time spent in the target quadrant. STS decreased the activity of acetylcholinesterase (AChE) and increased the activity of choline acetyltransferase (ChAT) in the hippocampus and cortex of SCOP-treated mice. Oxidative stress results showed that STS increased the activity of superoxide dismutase (SOD) and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in hippocampus and cortex. In addition, western blot was carried out to detect the expression of apoptosis related proteins (Bcl-2, Bax, and Caspase-3). STS upregulated the protein expression of Bcl-2 and downregulated the proteins expression of Bax and Caspase-3. These results indicated that STS might become a promising therapeutic candidate for attenuating AD-like pathological dysfunction.
- Subjects
PROTEIN analysis; ACETYLCHOLINESTERASE; ACETYLTRANSFERASES; REACTIVE oxygen species; ALZHEIMER'S disease; ANALYSIS of variance; ANIMAL behavior; ANIMAL experimentation; APOPTOSIS; BIOLOGICAL assay; CEREBRAL cortex; COGNITION disorders; HIPPOCAMPUS (Brain); HYDROCARBONS; LEARNING; RESEARCH methodology; MEMORY; MICE; MOLECULAR structure; PROBABILITY theory; PROTEOLYTIC enzymes; RESEARCH funding; SCOPOLAMINE; STAINS &; staining (Microscopy); STATISTICS; T-test (Statistics); TIME; TISSUE culture; WESTERN immunoblotting; DATA analysis; SULFUR acids; DATA analysis software; DONEPEZIL; DESCRIPTIVE statistics
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/9852536