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- Title
CD19/CD22 dual‐targeting chimeric antigen receptor T‐cell therapy bridging to allogeneic haematopoietic stem cell transplantation for B‐cell acute lymphoblastic leukaemia delays platelet recovery and increases risks of cytomegalovirus and Epstein–Barr virus viremia after transplantation
- Authors
Li, Shijia; Ge, Jianrong; Zhou, Shiyuan; Zhu, Wenjuan; Han, Yue; Chen, Suning; Xue, Shengli; Wang, Ying; Qiu, Huiying; Wu, Xiaojin; Wu, Depei
- Abstract
CD19/CD22 dual-targeting chimeric antigen receptor T-cell therapy bridging to allogeneic haematopoietic stem cell transplantation for B-cell acute lymphoblastic leukaemia delays platelet recovery and increases risks of cytomegalovirus and Epstein-Barr virus viremia after transplantation Twenty-nine patients received CD19 and CD22 dual-targeting CAR-T therapy prior to HSCT (CD19/CD22 dual-targeting CAR-T group), 43 patients received CD19 single-targeting CAR-T-cell therapy prior to HSCT (CD19 single-targeting CAR-T group) and 97 patients did not receive CAR-T therapy prior to transplantation (non-CAR-T group). Dear Editor, Chimeric antigen receptor T (CAR-T) cell therapy has been one of the most promising strategies to achieve improved complete remission (CR) in patients with refractory/relapsed B-cell acute lymphoblastic leukaemia (B-ALL) but remissions can be short-lived.[1] Increasing evidence gathered from recent studies has shown that CAR-T-cell therapy alongside complementary allo-haematopoietic stem cell transplantation (HSCT) may achieve more durable long-term remission than CAR-T-cell therapy alone.[2] However, whether this combinational therapy is capable of exerting its impact on HSCT-related complications remains unclear.
- Subjects
HEMATOPOIETIC stem cell transplantation; CHIMERIC antigen receptors; LYMPHOBLASTIC leukemia; BK virus; ACUTE leukemia; EPSTEIN-Barr virus
- Publication
Clinical & Translational Medicine, 2023, Vol 13, Issue 10, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1459