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- Title
Relative Movements of Domains in Large Molecules of the Immune System.
- Authors
Schreiner, Wolfgang; Karch, Rudolf; Ribarics, Reiner; Cibena, Michael; Ilieva, Nevena
- Abstract
Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were generated and directional cosines and Euler angles were computed. As a most interesting result, we found that the presence of the coreceptor seems to influence the dynamics within the protein complex, in particular the relative movements of the two α-helices, Gα1 and Gα2.
- Subjects
MAJOR histocompatibility complex; IMMUNE system; CD8 antigen; T cell receptors; MOLECULAR dynamics; MULTIPLE correspondence analysis (Statistics)
- Publication
Journal of Immunology Research, 2015, p210675
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2015/210675