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- Title
Epigenetic changes in the metabolically healthy obese: A case‐control versus a prospective study.
- Authors
Linares‐Pineda, Teresa Maria; Boughanem, Hatim; Gutiérrez‐Repiso, Carolina; Macías‐González, Manuel; Andrés‐León, Eduardo; Rojo‐Martínez, Gemma; Valdés, Sergio; Tinahones, Francisco J.; Morcillo, Sonsoles
- Abstract
DISCUSSION This study presented an epigenome-wide DNA methylation analysis for the epigenetic changes in the MUO phenotype, using both the case-control and prospective designs, with a follow-up of 11 years. Overall, in the case-control approach, we observed that the average global DNA methylation was decreased in the MUO group ( I p i < 0.001) (Figure 1C), whereas in the prospective design, individuals with MUO at 11-years follow-up showed increased average global DNA methylation in comparison with subjects at baseline (MHO) ( I p i < 0.001). Obesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. DNA isolation, bisulfite reaction and epigenome-wide DNA methylation analysis DNA was extracted from peripheral blood using the QIAmp DNA Blood Mini Kit (Qiagen, Hilden, Germany).
- Subjects
METABOLIC disorders; EPIGENETICS; LONGITUDINAL method
- Publication
European Journal of Clinical Investigation, 2022, Vol 52, Issue 8, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.13783