We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serum paraoxonase-1 activity is inversely related to free thyroxine in euthyroid subjects: The PREVEND Cohort Study.
- Authors
van Tienhoven‐Wind, Lynnda J. N.; Gruppen, Eke G.; James, Richard W.; Bakker, Stephan J. L.; Gans, Rijk O. B.; Dullaart, Robin P. F.
- Abstract
Background Low-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 ( PON-1) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with thyroid stimulating hormone ( TSH), free T4, free T3, lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS). Materials and methods Serum PON-1 activity (arylesterase activity), TSH, free T4, free T3, lipids and apoA-I was measured in 2206 euthyroid subjects (aged 28-75 years; 1138 men (age 49 ± 13 years) and 1068 women (age 46 ± 12 years), recruited from the general population ( PREVEND cohort). Results In age- and sex-adjusted analysis, PON-1 activity (divided into tertiles) was positively related to TSH (β = −0.045, P = .036) and inversely to free T4 (β = −0.042, P = .050) but not to free T3 (β = −0.027, P = .20). PON-1 activity was positively related to total cholesterol, non- HDL cholesterol and triglycerides, as well as to HDL cholesterol and apoA-I ( P < .01 to <.001). The inverse relationship of PON-1 activity with free T4 remained present after adjustment for lipids and other potential confounders (β = −0.066, P = .002), but the positive relationship with TSH lost significance (β = 0.034, P = .11). The inverse relationship of PON-1 activity with free T4 was not different in subjects with vs without MetS ( P = .94), nor modified by the presence of its individual components ( P ≥ .22 for each). Conclusions Serum PON-1 activity is inversely associated with free T4 in euthyroid subjects, suggesting that low-normal thyroid function may affect PON-1 regulation.
- Subjects
PARAOXONASE; THYROXINE; ATHEROSCLEROSIS; THYROTROPIN; APOLIPOPROTEINS; LIPOPROTEINS
- Publication
European Journal of Clinical Investigation, 2018, Vol 48, Issue 1, pn/a
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12860