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- Title
Antinociceptive and anti-inflammatory activity of α-d-mannan from Pseudozyma sp.
- Authors
Valasques Junior, Gildomar Lima; dos Santos, Jener David Gonçalves; Chaves, Pedro Felipe Pereira; Cordeiro, Lucimara Mach Côrtes; de Jesus, Cleisiane Lima; de Lima, Flávia Oliveira; Boffo, Elisangela Fabiana; de Assis, Sandra Aparecida
- Abstract
Pseudozyma sp. are yeasts that are commercially important due to their production of glycolipid biosurfactants, squalene, itaconic acid, and exopolysaccharide. The search for other analgesia inducing drugs, such as opiates and non-steroidal anti-inflammatory drugs (NSAIDs), as alternatives is beneficial. In this study, the antinociceptive and anti-inflammatory actions of α-d-mannan were studied using acetic acid-induced writhing, open field test, formalin test, and carrageenan-induced paw oedema tests in mice. The α-d-mannan obtained from Pseudozyma sp. was confirmed by methylation analysis, 1D and 2D NMR spectroscopic analysis, and GC–MS. The results show that α-d-mannan from Pseudozyma sp. has analgesic and anti-inflammatory activities.
- Subjects
GALACTOMANNANS; GLYCOLIPIDS; ITACONIC acid; ANTI-inflammatory agents; BIOSURFACTANTS; FORMALDEHYDE; SQUALENE
- Publication
3 Biotech, 2021, Vol 11, Issue 2, p1
- ISSN
2190-572X
- Publication type
Article
- DOI
10.1007/s13205-020-02635-1