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- Title
Membranoproliferative glomerulonephritis associated with a mutation in Wilms’ tumour suppressor gene 1.
- Authors
Bockenhauer, Detlef; van't Hoff, William; Chernin, Gil; Heeringa, Saskia F.; Sebire, Neil J.
- Abstract
Wilms’ tumour suppressor gene 1 ( WT1) encodes a transcription factor required for normal development of the genitourinary system. In the kidney, mutations in WT1 can cause diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Here, we report on a girl with a mutation in WT1, who developed membranoproliferative glomerulonephritis (MPGN) 3 years after completion of treatment for Wilms’ tumour. This finding extends the spectrum of glomerular disease seen with WT1 mutations and could have implications for the screening of children with MPGN.
- Subjects
GLOMERULONEPHRITIS; KIDNEY glomerulus diseases; IMMUNE complex diseases; TUMOR suppressor genes; TUMORS
- Publication
Pediatric Nephrology, 2009, Vol 24, Issue 7, p1399
- ISSN
0931-041X
- Publication type
Report
- DOI
10.1007/s00467-009-1135-8