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- Title
Crouzon with Acanthosis Nigricans and Odontogenic Tumors.
- Authors
Xu, Wen; McDonald-McGinn, Donna M.; Melchiorre, Alexandra J.; Zackai, Elaine H.; Bartlett, Scott P.; Taylor, Jesse A.
- Abstract
Crouzon syndrome with acanthosis nigricans (CAN) is caused by a mutation in the fibroblast growth factor receptor (FGFR) 3 gene that presents clinically as Crouzonoid craniofacial features in association with other anomalies such as acanthosis nigricans and benign odontogenic tumors. Diagnosis through the use of genetic mutational analysis is critical, as it alerts the surgeon to the need for careful screening for jaw tumors so that timely treatment in the form of curettage or segmental resection can be provided.
- Subjects
JAW tumors; CELL receptors; CRANIOFACIAL dysostosis; CRANIOSYNOSTOSES; MELANOSIS; GENETIC mutation; ODONTOGENIC tumors; SURGEONS; CURETTAGE; SEQUENCE analysis; DISEASE complications; CHILDREN; DIAGNOSIS
- Publication
Cleft Palate Craniofacial Journal, 2018, Vol 55, Issue 2, p296
- ISSN
1055-6656
- Publication type
Article
- DOI
10.1177/1055665617723918