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- Title
A Fundamental Relationship Between Geotype Frequencies and Fitnesses.
- Authors
Lachance, Joseph
- Abstract
The set of possible postselection genotype frequencies in an infinite, randomly mating population is found. Geometric mean heterozygote frequency divided by geometric mean homozygote frequency equals two times the geometric mean heterozygote fitness divided by geometric mean homozygote fitness. The ratio of genotype frequencies provides a measure of genetic variation that is independent of allele frequencies. When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes.
- Subjects
ZYGOTES; GENOTYPE-environment interaction; DATA; GEOMETRY; POPULATION
- Publication
Genetics, 2008, Vol 180, Issue 2, p1087
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.108.093518