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- Title
Serum oxidative and antioxidative status in patients with cataract.
- Authors
Saygili, E. İ; Aksoy, Ş. N.; Gürler, B.; Erel, O.
- Abstract
Oxidative stress is involved in development of many ocular diseases such as age-related macular degeneration, retinopathy of prematurity, retinal light damage and cataract. Reactive oxygen species are involved in this process. Oxidative stress is countered by antioxidants which are defined as substances that, at low concentrations relative to the substrate, inhibit the damage to the structural and functional molecules of the body, namely proteins, lipids, carbohydrates and DNA. In order to evaluate the relationship of total antioxidant status and total oxidant status with cataract, Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) were measured in sera of patients with cataract and healthy control subjects. The diabetic cataract patients' mean age was 62±12 years, the senile cataract patients' mean age was 66±8 years, the control groups' mean age was 64±8 years. Serum TAS and TOS levels were determined using a novel automated measurement method, developed by Erel. The percent ratio of the TOS to the TAS gave the oxidative stress index (OSI), an indicator of the degree of oxidative stress. TOS and OSI levels were significantly higher in diabetic cataract and higher in senile cataract subjects than in the control subjects (P < 0.001). TAC levels were lower in both diabetic cataract and senile cataract subjects than in the control subjects. But these differences were not significant when analyzed by student t test. The result of present study suggests that oxidative stress is responsible for the pathophysiology of cataract. It can be concluded that higher TOS activity could contribute to the higher risk of cataract formation. This possible pathophysiological association warrants further research.
- Publication
Cell Membranes & Free Radical Research, 2008, Vol 1, Issue 1, p37
- ISSN
1308-416X
- Publication type
Article