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- Title
Anticonvulsant Effect of Antiaris toxicaria (Pers.) Lesch. (Moraceae) Aqueous Extract in Rodents.
- Authors
Kolibea Mante, Priscilla; Wewura Adongo, Donatus; Woode, Eric; Edem Kukuia, Kennedy Kwami; Ofori Ameyaw, Elvis
- Abstract
Antiaris toxicaria (Moraceae) was evaluated for anticonvulsant activity in rodents. Animal models used include maximal electroshock test (MEST); pentylenetetrazole-induced (PTZ) convulsions; picrotoxin-induced (PCT) convulsions; strychnine-(STR-) and 4-aminopyridine-induced convulsions. Increase in latency to seizures as well as reduction in duration and frequency of seizures indicated anticonvulsant activity. The extract was more effective in all models used except the maximal electroshock test and strychnine-induced convulsions. Antiaris toxicaria aqueous extract (200, 400, and 800 mg kg-1) significantly (P < 0.05 - 0.01) shortened the duration of convulsions in PTZ- and PCT-induced seizures. Delay in the onset of convulsions in the two tests was significant (P < 0.001). Reduction in the frequency of seizures was also significant (P < 0.05 - 0.001) in both tests. Antiaris further delayed the onset of seizures in 4-aminopyridine model while producing 75% protection against death in mice. Diazepam (0.1, 0.3, and 1mg kg-1), carbamazepine (3, 10, and 30mg kg-1), and sodium valproate (100-400mg kg-1) were used as reference anticonvulsant drugs for various models. Flumazenil blocked the effect of the extract in the PTZ test significantly suggesting that Antiaris toxicaria may be acting by enhancing the effects of the GABAergic system. Antiaris toxicaria aqueous extract therefore possesses anticonvulsant activity.
- Subjects
ANTICONVULSANTS; UPAS; MORACEAE; RODENTS; AQUEOUS solutions; PICROTOXIN; SPASMS
- Publication
ISRN Pharmacology, 2013, p1
- ISSN
2090-5165
- Publication type
Article
- DOI
10.1155/2013/519208