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- Title
Effect of ginger on gastric motility and symptoms of functional dyspepsia.
- Authors
Ming-Luen Hu; Rayner, Christophan K.; Keng-Liang Wu; Seng-Kee Chuah; Wei-Chen Tai; Yeh-Pin Chou; Yi-Chun Chiu; King-Wah Chiu; Tsung-Hui Hu
- Abstract
AIM: To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia. METHODS: Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules that contained ginger (total 1.2 g) or placebo, followed after 1 h by 500 mL low-nutrient soup. Antral area, fundus area and diameter, and the frequency of antral contractions were measured using ultrasound at frequent intervals, and the gastric half-emptying time was calculated from the change in antral area. Gastrointestinal sensations and appetite were scored using visual analog questionnaires, and blood was taken for measurement of plasma glucagon-like peptide-1 (GLP-1), motilin and ghrelin concentrations, at intervals throughout the study. RESULTS: Gastric emptying was more rapid after ginger than placebo [median (range) half-emptying time 12.3 (8.5-17.0) min after ginger, 16.1 (8.3-22.6) min after placebo, P ⩽ 0.05]. There was a trend for more antral contractions (P = 0.06), but fundus dimensions and gastrointestinal symptoms did not differ, nor did serum concentrations of GLP-1, motilin and ghrelin. CONCLUSION: Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia, but had no impact on gastrointestinal symptoms or gut peptides.
- Subjects
GASTROINTESTINAL motility; GINGER; GASTROINTESTINAL system; SYMPTOMS; GLUCAGON-like peptide 1; INDIGESTION
- Publication
Annals of Gastroenterology & Hepatology, 2011, Vol 9, Issue 95, p105
- ISSN
2043-023X
- Publication type
Article
- DOI
10.3748/wjg.v17.i1.105