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- Title
Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies.
- Authors
Gheonea, Dan Ionuţ; Cârţână, Tatiana; Ciurea, Tudorel; Popescu, Carmen; Bădărău, Anca; Săftoiu, Adrian
- Abstract
Gastrointestinal cancers represent a major cause of morbidity and mortality, with incomplete response to chemotherapy in the advanced stages and poor prognosis. Angiogenesis plays a crucial part in tumor growth and metastasis, with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network. Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents. Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination (immunoendoscopy), as a future challenge, will add functional analysis to the morphological aspect of the neoplastic process. This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization, resulting in a broad spectrum of potential clinical applications, and also preclinical research that could be translated to human studies.
- Subjects
CONFOCAL microscopy; ENDOSCOPY; GASTROINTESTINAL cancer; GASTROINTESTINAL cancer treatment; CANCER chemotherapy; CANCER-related mortality; TUMOR growth; BIOMARKERS; PROGNOSIS
- Publication
Annals of Gastroenterology & Hepatology, 2011, Vol 9, Issue 91, p21
- ISSN
2043-023X
- Publication type
Article
- DOI
10.3748/wjg.v17.i1.21