We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation.
- Authors
Xiaoyan Liao; Haghighi, Parviz; Coffey, Charles S.; Xiangdong Xu
- Abstract
Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. The oncocytic variant of mucoepidermoid carcinoma (OMEC) is rare and a small subset shows exclusive oncocytic morphology. Here we report an OMEC case of the parotid gland in a 74-year-old woman with exclusive oncocytes and rare mucocytes. The oncocytes showed diffuse nuclear positivity with p63 immunostaining. The MAML2 translocation was present, supporting the diagnosis of OMEC. Distinguishing OMEC with exclusive oncocytes from oncocytoma and oncocytic carcinoma can be very challenging for patholo-gists and is critical for proper clinical management. Our experience suggests that appropriate ancillary studies, especially the MAML2 translocation, may provide the essential evidence in difficult cases. Our literature review shows that the presence of mucocytes in an oncocytic neoplasm might be an important morphologic clue of OMEC.
- Subjects
SALIVARY gland cancer; IMMUNOSTAINING; CHROMOSOMAL translocation; DIAGNOSIS
- Publication
Rare Tumors, 2016, Vol 8, Issue 2, p66
- ISSN
2036-3605
- Publication type
Case Study
- DOI
10.4081/rt.2016.6166