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- Title
Postmortem Cerebrospinal Fluid Pleocytosis: A Marker of Inflammation or Postmortem Artifact?
- Authors
Morris, James A.; Harrison, Linda M.; Telford, David R.
- Abstract
The aim of this paper is to reassess the significance of postmortem cerebrospinal fluid pleocytosis. Published articles of CSF changes after death were reviewed, and reanalysis, in the light of modern views on the significance of bacterial postmortem isolates, was undertaken. There is theoretical and experimental evidence that the blood brain barrier to the movement of protein and cells is preserved in the first few hours after death. The number of mononuclear cells in the cerebrospinal fluid does rise in the first 24 hours after death, and this is most probably due to detachment of leptomeningeal lining cells. But the marked increase in lymphocyte counts seen in some cases of sudden infant death syndrome (SIDS) and in other deaths in the paediatric age range could well be a marker of inflammation.
- Subjects
CEREBROSPINAL fluid; BIOMARKERS; AUTOPSY; INFLAMMATION; LYMPHOCYTE count; BLOOD-brain barrier
- Publication
International Journal of Pediatrics, 2012, p1
- ISSN
1687-9740
- Publication type
Article
- DOI
10.1155/2012/964074