We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia.
- Authors
Gouvêa, Adriele Ferreira; Vargas, Pablo Agustin; Coletta, Ricardo D.; Jorge, Jacks; Lopes, Márcio Ajudarte
- Abstract
J Oral Pathol Med (2010) 39: 447–452 Background: Proliferative verrucous leukoplakia (PVL) is a distinct and aggressive type of oral leukoplakia which affects elderly women without risk behavior and presents high rates of malignant transformation. The objective of the present study was to evaluate the clinicopathological characteristics and the distribution of cell proliferation markers, aiming to elucidate the distinct biological behavior of the PVL. Methods: Clinical and microscopical features of 12 patients with PVL were reviewed. Immunohistochemical analysis for p53, Ki-67, Mcm-2 and Mcm-5 were performed and the data were correlated. Results: All patients were women, above 50 years of age, 91.7% were non-smoker and 100% were non-habitual drinker. Alveolar ridge (66.6%), tongue (50%) and buccal mucosa (41.6%) were the most affected sites. Four patients developed squamous cell carcinoma (SCC). The immunohistochemical findings showed higher positivity for p53, Ki-67, Mcm-2 and Mcm-5 in SCCs. However, some patients with mild or moderate dysplasia, specially the patients who developed SCC, presented high expression of Mcm-2 and Mcm-5. Conclusions: High immunoexpression of Mcm-2 and Mcm-5 in mild and moderate dysplasia could be helpful to predict the malignant transformation of PVL.
- Subjects
LEUKOPLAKIA; DYSPLASIA; SQUAMOUS cell carcinoma; GENE expression; IMMUNOHISTOCHEMISTRY techniques; CELL transformation
- Publication
Journal of Oral Pathology & Medicine, 2010, Vol 39, Issue 6, p447
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.2010.00889.x