We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea.
- Authors
Chia-Ching Liaw; Yuan-Bin Cheng; Yun-Sheng Lin; Yao-Haur Kuo; Tsong-Long Hwang; Ya-Ching Shen
- Abstract
Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4ß-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (¹H- and 13C-NMR, ¹H-¹H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/ Cytochalasin B (fMLP/CB).
- Subjects
DITERPENES; ALCYONACEA; LIPID analysis; ANTI-inflammatory agents; MARINE natural products
- Publication
Marine Drugs, 2014, Vol 12, Issue 8, p4677
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12084677