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- Title
The Role of Biophysical Parameters in the Antilipopolysaccharide Activities of Antimicrobial Peptides from Marine Fish.
- Authors
Gopal, Ramamourthy; Chang Ho Seo; Yoonkyung Park
- Abstract
Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties of AMPs. In this review, therefore, we will focus on the physiochemical properties of AMPs; that is, the contributions made by their sequences, net charge, hydrophobicity and amphipathicity to their mechanism of action. Moreover, the interactions between LPS and fish AMPs and the structure of fish AMPs with LPS bound will also be discussed. A better understanding of the biophysical properties will be useful in the design of AMPs effective against septic shock and multidrug-resistant bacterial strains, including those that commonly produce wound infections.
- Subjects
PHYSICAL biochemistry; MARINE fishes; ANTI-infective agents; LIPOPOLYSACCHARIDES; WOUND infections
- Publication
Marine Drugs, 2014, Vol 12, Issue 3, p1471
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12031471