We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
CD4-T-Lymphocyte Reference Ranges in Uganda and Its Influencing Factors.
- Authors
Nanzigu, Sarah; Waako, Paul; Petzold, Max; Kiwanuka, Gertrude; Dungu, Henry; Makumbi, Fred; Gustafsson, Lars L.; Eriksen, Jaran
- Abstract
Background: Given the importance of CD4-T-lymphocyte monitoring in HIV/ART management, we established CD4/CD8 reference ranges in Uganda and studied factors associated with CD4/CD8 in a normal population. Methods: Blood samples for 206 HIV seronegative healthy volunteers from the Mbarara and Kampala districts in Uganda were analyzed using the PanLeucogating protocol. Results: The reference ranges reported include data from 172 participants with no current or serious recent health problems. The 95% reference ranges for absolute CD4 (ACD4) count was 418-2105 cells/μL, 256-1619 for absolute CD8 count, and 0.52-4.1 for CD4/CD8 cell ratio, which is wider than the reference ranges currently used in Uganda. Recent illnesses/medications and socio-demographic factors affected the CD4-T-lymphocyte count. Conclusion: The CD4 reference ranges in Uganda were established using a cost-effective method, recommended and available in resource-limited settings. Effect of prevalent infections and socio-demographic differences on CD4-T-lymphocyte levels would need consideration in HIV/ART clinical management.
- Subjects
UGANDA; BLOOD cell count; CONFIDENCE intervals; FLOW cytometry; HIV; LYMPHOCYTES; NEUTROPHILS; PROBABILITY theory; QUESTIONNAIRES; REFERENCE values; REGRESSION analysis; RESEARCH funding; SEROLOGY; T cells; T-test (Statistics); CYTOMETRY; SOCIOECONOMIC factors; DATA analysis software
- Publication
Laboratory Medicine, 2011, Vol 42, Issue 2, p94
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1309/LMFT0VCE1UGO9YGD