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Do amiodarone and dronedarone prevent thrombo-embolic stroke by treating the atrial myopathy of patients with atrial fibrillation? A provocative hypothesis.
Published in:
2020
By:
- Packer, Milton
Publication type:
journal article
Effects of Initiating Carvedilol in Patients With Severe Chronic Heart Failure: Results From the COPERNICUS Study.
Published in:
JAMA: Journal of the American Medical Association, 2003, v. 289, n. 6, p. 712, doi. 10.1001/jama.289.6.712
By:
- Krum, Henry;
- Roecker, Ellen B.;
- Mohacsi, Paul;
- Rouleau, Jean L.;
- Tendera, Michal;
- Coats, Andrew J. S.;
- Katus, Hugo A.;
- Fowler, Michael B.;
- Packer, Milton
Publication type:
Article
Glucagon-Like Peptide-1 Receptor Agonists Across the Spectrum of Heart Failure.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 1, p. 4, doi. 10.1210/clinem/dgad398
By:
- Ferreira, João Pedro;
- Sharma, Abhinav;
- Butler, Javed;
- Packer, Milton;
- Zannad, Faiez;
- Vasques-Nóvoa, Francisco;
- Leite-Moreira, Adelino;
- Neves, João Sérgio
Publication type:
Article
Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs.
Published in:
Cardiovascular Diabetology, 2020, v. 19, n. 1, p. 1, doi. 10.1186/s12933-020-01041-4
By:
- Packer, Milton
Publication type:
Article
Disease–treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation: the potential mediating influence of epicardial adipose tissue.
Published in:
Cardiovascular Diabetology, 2019, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12933-019-0927-9
By:
- Packer, Milton
Publication type:
Article
Lessons learned from the DAPA-HF trial concerning the mechanisms of benefit of SGLT2 inhibitors on heart failure events in the context of other large-scale trials nearing completion.
Published in:
2019
By:
- Packer, Milton
Publication type:
Editorial
Development of autophagy inducers in clinical medicine.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 1, p. 14, doi. 10.1172/JCI73938
By:
- Levine, Beth;
- Packer, Milton;
- Codogno, Patrice
Publication type:
Article
Selection Bias in the Use of Thrombolytic Therapy in Acute Myocardial Infarction.
Published in:
JAMA: Journal of the American Medical Association, 1991, v. 266, n. 4, p. 528, doi. 10.1001/jama.1991.03470040092028
By:
- Pfeffer, Marc A.;
- Moye, Lemuel A.;
- Braunwald, Eugene;
- Basta, Lofty;
- Brown Jr., Edward J.;
- Cuddy, Thomas E.;
- Dagenais, Gilles R.;
- Flaker, Gregory C.;
- Geltman, Edward M.;
- Gersh, Bernard J.;
- Goldman, Setevn;
- Lamas, Gervasio A.;
- Packer, Milton;
- Rouleau, Jean L.;
- Rutherford, John D.;
- Steingart, Richard M.;
- Wertheimer, John H.
Publication type:
Article
Adverse hemodynamic and clinical effects of encainide in severe chronic heart failure.
Published in:
1989
By:
- Gottlieb, Stephen S.;
- Kulkin, Marrick L.;
- Yushak, Madeline;
- Medina, Norma;
- Packer, Milton;
- Gottlieb, S S;
- Kukin, M L;
- Yushak, M;
- Medina, N;
- Packer, M
Publication type:
journal article
Clinical trials in congestive heart failure: why do studies report conflicting results?
Published in:
1988
By:
- Packer, Milton;
- Packer, M
Publication type:
journal article
Functional renal insufficiency during long-term therapy with captopril and enalapril in severe chronic heart failure.
Published in:
1987
By:
- Packer, Milton;
- Wai Hung Lee;
- Medina, Norma;
- Yushak, Madeline;
- Kessler, Paul D.;
- Packer, M;
- Lee, W H;
- Medina, N;
- Yushak, M;
- Kessler, P D
Publication type:
journal article
Influence of Renal Function on the Hemodynamic and Clinical Responses to Long-Term Captopril Therapy in Severe Chronic Heart Failure.
Published in:
Annals of Internal Medicine, 1986, v. 104, n. 2, p. 147, doi. 10.7326/0003-4819-104-2-147
By:
- Packer, Milton;
- Wai Hung Lee;
- Medina, Norma;
- Yushak, Madeline
Publication type:
Article
Vasodilator Therapy for Primary Pulmonary Hypertension.
Published in:
Annals of Internal Medicine, 1985, v. 103, n. 2, p. 258, doi. 10.7326/0003-4819-103-2-258
By:
- Packer, Milton
Publication type:
Article
Correction of Dilutional Hyponatremia in Severe Chronic Heart Failure by Converting-Enzyme Inhibition.
Published in:
Annals of Internal Medicine, 1984, v. 100, n. 6, p. 782, doi. 10.7326/0003-4819-100-6-782
By:
- Packer, Milton;
- Medina, Norma;
- Yushak, Madeline
Publication type:
Article
Lack of durable natriuresis and objective decongestion following SGLT2 inhibition in randomized controlled trials of patients with heart failure.
Published in:
Cardiovascular Diabetology, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12933-023-01946-w
By:
- Packer, Milton
Publication type:
Article
Impact of empagliflozin on insulin needs in patients with heart failure and diabetes: An EMPEROR‐Pooled analysis.
Published in:
Diabetes, Obesity & Metabolism, 2024, v. 26, n. 7, p. 2578, doi. 10.1111/dom.15572
By:
- Talha, Khawaja M.;
- Green, Jennifer;
- Filippatos, Gerasimos;
- Pocock, Stuart;
- Zannad, Faiez;
- Brueckmann, Martina;
- Schueler, Elke;
- Ofstad, Anne Pernille;
- Ferreira, João Pedro;
- Anker, Stefan D.;
- Butler, Javed;
- Rosenstock, Julio;
- Packer, Milton
Publication type:
Article
Glucagon‐like peptide 1 receptor agonists in patients with type 2 diabetes with and without chronic heart failure: A meta‐analysis of randomized placebo‐controlled outcome trials.
Published in:
Diabetes, Obesity & Metabolism, 2023, v. 25, n. 6, p. 1495, doi. 10.1111/dom.14997
By:
- Ferreira, João Pedro;
- Saraiva, Francisca;
- Sharma, Abhinav;
- Vasques‐Nóvoa, Francisco;
- Angélico‐Gonçalves, António;
- Leite, Ana Rita;
- Borges‐Canha, Marta;
- Carvalho, Davide;
- Packer, Milton;
- Zannad, Faiez;
- Leite‐Moreira, Adelino;
- Neves, João Sérgio
Publication type:
Article
Alleviation of functional iron deficiency by SGLT2 inhibition in patients with type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2023, v. 25, n. 5, p. 1143, doi. 10.1111/dom.14963
By:
- Packer, Milton
Publication type:
Article
Risk of adverse events with liraglutide in heart failure with reduced ejection fraction: A post hoc analysis of the FIGHT trial.
Published in:
Diabetes, Obesity & Metabolism, 2023, v. 25, n. 1, p. 189, doi. 10.1111/dom.14862
By:
- Neves, João Sérgio;
- Vasques‐Nóvoa, Francisco;
- Borges‐Canha, Marta;
- Leite, Ana Rita;
- Sharma, Abhinav;
- Carvalho, Davide;
- Packer, Milton;
- Zannad, Faiez;
- Leite‐Moreira, Adelino;
- Ferreira, João Pedro
Publication type:
Article
Interplay of adenosine monophosphate‐activated protein kinase/sirtuin‐1 activation and sodium influx inhibition mediates the renal benefits of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes: A novel conceptual framework
Published in:
Diabetes, Obesity & Metabolism, 2020, v. 22, n. 5, p. 734, doi. 10.1111/dom.13961
By:
- Packer, Milton
Publication type:
Article
Critical role of the epicardium in mediating cardiac inflammation and fibrosis in patients with type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2019, v. 21, n. 8, p. 1765, doi. 10.1111/dom.13792
By:
- Packer, Milton
Publication type:
Article
Higher mortality rate in patients with heart failure who are taking commonly prescribed antidiabetic medications and achieve recommended levels of glycaemic control.
Published in:
Diabetes, Obesity & Metabolism, 2018, v. 20, n. 7, p. 1766, doi. 10.1111/dom.13265
By:
- Packer, Milton
Publication type:
Article
Do sodium‐glucose co‐transporter‐2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis.
Published in:
Diabetes, Obesity & Metabolism, 2018, v. 20, n. 6, p. 1361, doi. 10.1111/dom.13229
By:
- Packer, Milton
Publication type:
Article
Have we really demonstrated the cardiovascular safety of anti‐hyperglycaemic drugs? Rethinking the concepts of macrovascular and microvascular disease in type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2018, v. 20, n. 5, p. 1089, doi. 10.1111/dom.13207
By:
- Packer, Milton
Publication type:
Article
Role of the sodium‐hydrogen exchanger in mediating the renal effects of drugs commonly used in the treatment of type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2018, v. 20, n. 4, p. 800, doi. 10.1111/dom.13191
By:
- Packer, Milton
Publication type:
Article
How carvedilol does not activate β<sub>2</sub>-adrenoceptors.
Published in:
2023
By:
- Lefkowitz, Robert J.;
- Rockman, Howard A.;
- Shim, Paul J.;
- Liu, Samuel;
- Ahn, Seungkirl;
- Pani, Biswaranjan;
- Rajagopal, Sudarshan;
- Shenoy, Sudha K.;
- Bouvier, Michel;
- Benovic, Jeffrey L.;
- Liggett, Stephen B.;
- Ruffolo, Robert R.;
- Bristow, Michael R.;
- Packer, Milton
Publication type:
Letter
Traditional Chinese medicine: cardiovascular drug development through a holistic framework.
Published in:
European Heart Journal, 2024, v. 45, n. 40, p. 4315, doi. 10.1093/eurheartj/ehae625
By:
- Packer, Milton
Publication type:
Article
Identification of three mechanistic pathways for iron-deficient heart failure.
Published in:
European Heart Journal, 2024, v. 45, n. 26, p. 2281, doi. 10.1093/eurheartj/ehae284
By:
- Packer, Milton;
- Anker, Stefan D;
- Butler, Javed;
- Cleland, John G F;
- Kalra, Paul R;
- Mentz, Robert J;
- Ponikowski, Piotr
Publication type:
Article
Great Debate: SGLT2 inhibitors should be first-line treatment in heart failure with reduced ejection fraction.
Published in:
European Heart Journal, 2024, v. 45, n. 25, p. 2186, doi. 10.1093/eurheartj/ehae300
By:
- Packer, Milton;
- Cleland, John G F;
- Bauersachs, Johann
Publication type:
Article
Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium–glucose cotransporter 2 inhibitors.
Published in:
European Heart Journal, 2023, v. 44, n. 48, p. 5027, doi. 10.1093/eurheartj/ehad235
By:
- Packer, Milton
Publication type:
Article
Acetazolamide for acute heart failure: is ADVOR a riddle wrapped in a mystery inside an enigma?
Published in:
European Heart Journal, 2023, v. 44, n. 37, p. 3683, doi. 10.1093/eurheartj/ehad560
By:
- Bueno, Héctor;
- Packer, Milton
Publication type:
Article
Stroke in patients with heart failure and reduced or preserved ejection fraction.
Published in:
European Heart Journal, 2023, v. 44, n. 31, p. 2998, doi. 10.1093/eurheartj/ehad338
By:
- Yang, Mingming;
- Kondo, Toru;
- Butt, Jawad H;
- Abraham, William T;
- Anand, Inder S;
- Desai, Akshay S;
- Køber, Lars;
- Packer, Milton;
- Pfeffer, Marc A;
- Rouleau, Jean L;
- Sabatine, Marc S;
- Solomon, Scott D;
- Swedberg, Karl;
- Zile, Michael R;
- Jhund, Pardeep S;
- McMurray, John J V
Publication type:
Article
Importance of cystatin C in estimating glomerular filtration rate: the PARADIGM-HF trial.
Published in:
European Heart Journal, 2023, v. 44, n. 24, p. 2202, doi. 10.1093/eurheartj/ehad210
By:
- Tolomeo, Paolo;
- Butt, Jawad H;
- Kondo, Toru;
- Campo, Gianluca;
- Desai, Akshay S;
- Jhund, Pardeep S;
- Køber, Lars;
- Lefkowitz, Martin P;
- Rouleau, Jean L;
- Solomon, Scott D;
- Swedberg, Karl;
- Vaduganathan, Muthiah;
- Zile, Michael R;
- Packer, Milton;
- McMurray, John J V
Publication type:
Article
Drugs that slow the progression of diabetic kidney disease: are renoprotective effects attenuated in heart failure?
Published in:
European Heart Journal, 2023, v. 44, n. 17, p. 1522, doi. 10.1093/eurheartj/ehad158
By:
- Packer, Milton;
- Siddiqi, Tariq Jamal;
- Butler, Javed
Publication type:
Article
Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox.
Published in:
European Heart Journal, 2023, v. 44, n. 13, p. 1136, doi. 10.1093/eurheartj/ehad083
By:
- Butt, Jawad H;
- Petrie, Mark C;
- Jhund, Pardeep S;
- Sattar, Naveed;
- Desai, Akshay S;
- Køber, Lars;
- Rouleau, Jean L;
- Swedberg, Karl;
- Zile, Michael R;
- Solomon, Scott D;
- Packer, Milton;
- McMurray, John J V
Publication type:
Article
Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction.
Published in:
European Heart Journal, 2023, v. 44, n. 8, p. 668, doi. 10.1093/eurheartj/ehac801
By:
- Curtain, James P;
- Adamson, Carly;
- Kondo, Toru;
- Butt, Jawad Haider;
- Desai, Akshay S;
- Zannad, Faiez;
- Rouleau, Jean L;
- Rohde, Luis E;
- Kober, Lars;
- Anand, Inder S;
- Veldhuisen, Dirk J van;
- Zile, Michael R;
- Lefkowitz, Martin P;
- Solomon, Scott D;
- Packer, Milton;
- Petrie, Mark C;
- Jhund, Pardeep S;
- McMurray, John J V
Publication type:
Article
Empagliflozin, irrespective of blood pressure, improves outcomes in heart failure with preserved ejection fraction: the EMPEROR-Preserved trial.
Published in:
European Heart Journal, 2023, v. 44, n. 5, p. 396, doi. 10.1093/eurheartj/ehac693
By:
- Bhm, Michael;
- Anker, Stefan;
- Mahfoud, Felix;
- Lauder, Lucas;
- Filippatos, Gerasimos;
- Ferreira, Joo Pedro;
- Pocock, Stuart J;
- Brueckmann, Martina;
- Saloustros, Ilias;
- Schler, Elke;
- Wanner, Christoph;
- Zannad, Faiez;
- Packer, Milton;
- Butler, Javed
Publication type:
Article
Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme.
Published in:
European Heart Journal, 2022, v. 43, n. 48, p. 4991, doi. 10.1093/eurheartj/ehac495
By:
- Zannad, Faiez;
- Ferreira, João Pedro;
- Butler, Javed;
- Filippatos, Gerasimos;
- Januzzi, James L;
- Sumin, Mikhail;
- Zwick, Matthias;
- Saadati, Maral;
- Pocock, Stuart J;
- Sattar, Naveed;
- Anker, Stefan D;
- Packer, Milton
Publication type:
Article
Predicting stroke in heart failure and reduced ejection fraction without atrial fibrillation.
Published in:
European Heart Journal, 2022, v. 43, n. 42, p. 4469, doi. 10.1093/eurheartj/ehac487
By:
- Kondo, Toru;
- Abdul-Rahim, Azmil H;
- Talebi, Atefeh;
- Abraham, William T;
- Desai, Akshay S;
- Dickstein, Kenneth;
- Inzucchi, Silvio E;
- Køber, Lars;
- Kosiborod, Mikhail N;
- Martinez, Felipe A;
- Packer, Milton;
- Petrie, Mark;
- Ponikowski, Piotr;
- Rouleau, Jean L;
- Sabatine, Marc S;
- Swedberg, Karl;
- Zile, Michael R;
- Solomon, Scott D;
- Jhund, Pardeep S;
- McMurray, John J V
Publication type:
Article
Potassium binders for patients with heart failure? The real enlightenment of the DIAMOND trial.
Published in:
European Heart Journal, 2022, v. 43, n. 41, p. 4374, doi. 10.1093/eurheartj/ehac399
By:
- Packer, Milton
Publication type:
Article
Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial.
Published in:
European Heart Journal, 2022, v. 43, n. 36, p. 3435, doi. 10.1093/eurheartj/ehac320
By:
- Doehner, Wolfram;
- Anker, Stefan D;
- Butler, Javed;
- Zannad, Faiez;
- Filippatos, Gerasimos;
- Ferreira, João Pedro;
- Salsali, Afshin;
- Kaempfer, Carolyn;
- Brueckmann, Martina;
- Pocock, Stuart J;
- Januzzi, James L;
- Packer, Milton
Publication type:
Article
Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled.
Published in:
European Heart Journal, 2022, v. 43, n. 31, p. 2984, doi. 10.1093/eurheartj/ehac306
By:
- Ferreira, João Pedro;
- Zannad, Faiez;
- Butler, Javed;
- Filipattos, Gerasimos;
- Ritter, Ivana;
- Schüler, Elke;
- Kraus, Bettina J;
- Pocock, Stuart J;
- Anker, Stefan D;
- Packer, Milton
Publication type:
Article
Accelerated and personalized therapy for heart failure with reduced ejection fraction.
Published in:
European Heart Journal, 2022, v. 43, n. 27, p. 2573, doi. 10.1093/eurheartj/ehac210
By:
- Shen, Li;
- Jhund, Pardeep Singh;
- Docherty, Kieran Francis;
- Vaduganathan, Muthiah;
- Petrie, Mark Colquhoun;
- Desai, Akshay Suvas;
- Køber, Lars;
- Schou, Morten;
- Packer, Milton;
- Solomon, Scott David;
- Zhang, Xingwei;
- McMurray, John Joseph Valentine
Publication type:
Article
Kidney function assessment and endpoint ascertainment in clinical trials.
Published in:
European Heart Journal, 2022, v. 43, n. 14, p. 1379, doi. 10.1093/eurheartj/ehab832
By:
- Khan, Muhammad Shahzeb;
- Bakris, George L;
- Packer, Milton;
- Shahid, Izza;
- Anker, Stefan D;
- Fonarow, Gregg C;
- Wanner, Christoph;
- Weir, Matthew R;
- Zannad, Faiez;
- Butler, Javed
Publication type:
Article
Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction.
Published in:
European Heart Journal, 2022, v. 43, n. 5, p. 416, doi. 10.1093/eurheartj/ehab798
By:
- Butler, Javed;
- Packer, Milton;
- Filippatos, Gerasimos;
- Ferreira, Joao Pedro;
- Zeller, Cordula;
- Schnee, Janet;
- Brueckmann, Martina;
- Pocock, Stuart J;
- Zannad, Faiez;
- Anker, Stefan D
Publication type:
Article
Sodium glucose co-transporter inhibitors and heart failure outcomes across different patient populations.
Published in:
European Heart Journal, 2021, v. 42, n. 48, p. 4887, doi. 10.1093/eurheartj/ehab704
By:
- Butler, Javed;
- Anker, Stefan D;
- Filippatos, Gerasimos;
- Usman, Muhammad Shariq;
- Ferreira, Joao Pedro;
- Zannad, Faiez;
- Packer, Milton
Publication type:
Article
Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial.
Published in:
European Heart Journal, 2021, v. 42, n. 43, p. 4455, doi. 10.1093/eurheartj/ehab579
By:
- Pocock, Stuart J;
- Ferreira, João Pedro;
- Gregson, John;
- Anker, Stefan D;
- Butler, Javed;
- Filippatos, Gerasimos;
- Gollop, Nicholas D;
- Iwata, Tomoko;
- Brueckmann, Martina;
- Januzzi, James L;
- Voors, Adriaan A;
- Zannad, Faiez;
- Packer, Milton
Publication type:
Article
Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial.
Published in:
European Heart Journal, 2021, v. 42, n. 43, p. 4442, doi. 10.1093/eurheartj/ehab360
By:
- Lam, Carolyn S P;
- Ferreira, João Pedro;
- Pfarr, Egon;
- Sim, David;
- Tsutsui, Hiroyuki;
- Anker, Stefan D;
- Butler, Javed;
- Filippatos, Gerasimos;
- Pocock, Stuart J;
- Sattar, Naveed;
- Verma, Subodh;
- Brueckmann, Martina;
- Schnee, Janet;
- Cotton, Daniel;
- Zannad, Faiez;
- Packer, Milton
Publication type:
Article
Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial.
Published in:
European Heart Journal, 2021, v. 42, n. 13, p. 1203, doi. 10.1093/eurheartj/ehaa1007
By:
- Butler, Javed;
- Anker, Stefan D;
- Filippatos, Gerasimos;
- Khan, Muhammad Shahzeb;
- Ferreira, João Pedro;
- Pocock, Stuart J;
- Giannetti, Nadia;
- Januzzi, James L;
- Piña, Ileana L;
- Lam, Carolyn S P;
- Ponikowski, Piotr;
- Sattar, Naveed;
- Verma, Subodh;
- Brueckmann, Martina;
- Jamal, Waheed;
- Vedin, Ola;
- Peil, Barbara;
- Zeller, Cordula;
- Zannad, Faiez;
- Packer, Milton
Publication type:
Article
Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial.
Published in:
European Heart Journal, 2021, v. 42, n. 6, p. 671, doi. 10.1093/eurheartj/ehaa968
By:
- Packer, Milton;
- Anker, Stefan D;
- Butler, Javed;
- Filippatos, Gerasimos;
- Ferreira, Joao Pedro;
- Pocock, Stuart J;
- Rocca, Hans-Peter Brunner-La;
- Janssens, Stefan;
- Tsutsui, Hiroyuki;
- Zhang, Jian;
- Brueckmann, Martina;
- Jamal, Waheed;
- Cotton, Daniel;
- Iwata, Tomoko;
- Schnee, Janet;
- Zannad, Faiez;
- Investigators, for the EMPEROR-Reduced Trial Committees and
Publication type:
Article

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