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- Title
Participation of microRNA 124-CREB pathway: a parallel memory enhancing mechanism of standardised extract of Bacopa monniera (BESEB CDRI-08).
- Authors
Preethi, Jayakumar; Singh, Hemant; Charles, Prisila; Emmanuvel Rajan, Koilmani
- Abstract
Bacosides, the effective component of standardised leaf extract of Bacopa monniera (BESEB CDRI-08) has been reported to have memory enhancing effect. Our previous reports suggested that BESEB CDRI-08 (BME) improves memory in postnatal rats by enhancing serotonin [5-hydroxytryptamine (5-HT)] metabolism, its transportation and subsequently activates 5-HT receptor during hippocampus-dependent learning. In this study, we examine whether the up-regulated 5-HT receptor activity by BME modulate microRNA 124-CREB pathway to enhance synaptic plasticity. Wistar rat pups received single dose of vehicle solution (0.5 % gum acacia + 0.9 % saline)/BME (80 mg/kg)/ mCPBG (10 mg/kg)/BME + mCPBG during the postnatal days (PND) 15-29. On PND 30, individuals were trained at brightness discrimination task and 24 h later, they were tested on the task. The BME treated group exhibited significantly lower percentage of errors during retention than acquisition. In addition, pre-miR-124 expression in hippocampus was significantly down-regulated in the BME and mCPBG + BME treated groups combined with a significant increase in the plasticity related genes, cAMP response element-binding protein, its phosphorylation and postsynaptic density protein 95. Our results suggest that this may be one of the mechanisms of bacosides present in BME for the memory enhancement.
- Subjects
MICRORNA; PLANTAGINACEAE; PLANT extracts; DRUG efficacy; DRUG metabolism; HIPPOCAMPUS (Brain); POSTSYNAPTIC density protein; LABORATORY rats
- Publication
Neurochemical Research, 2012, Vol 37, Issue 10, p2167
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-012-0840-z