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- Title
Neurochemical Plasticity of Nitric Oxide Synthase Isoforms in Neurogenic Detrusor Overactivity after Spinal Cord Injury.
- Authors
Zhang, Fan; Liao, Limin; Ju, Yanhe; Song, Aili; Liu, Yu
- Abstract
Nitric oxide (NO) participates in the neural pathways controlling the lower urinary tract (LUT). Expression of NO synthase (NOS) can be upregulated after spinal cord injury (SCI), and altered NOS activity may participate in resulting LUT dysfunction. To investigate distribution of NOS-immunoreactivity (NOS-IR) in neurons of rats following SCI and the possible effects of NOS inhibitors. Expression of neuronal and inducible NOS-IR in lumbosacral spinal cord was assessed in rats. Cystometry was performed to examine effects of intrathecal injection of NOS inhibitor. There was increased expression of neuronal NOS-IR after trauma. Maximum bladder capacity was increased by neuronal NOS (nNOS) inhibitors. Upregulation of nNOS may facilitate emergence of the spinal micturition reflex following SCI; nNOS inhibitor suppressed SCI-induced urinary incontinence by increasing bladder capacity. Our results indicate manipulation of NO production could help treat LUT dysfunction after SCI.
- Subjects
NEUROCHEMISTRY; MATERIAL plasticity; NITRIC oxide; NEURAL pathways; SPINAL cord injuries; URINARY organs; LABORATORY rats; URINARY incontinence
- Publication
Neurochemical Research, 2011, Vol 36, Issue 10, p1903
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-011-0512-4