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- Title
ONE SHOT - single shot radiotherapy for localized prostate cancer: study protocol of a single arm, multicenter phase I/II trial.
- Authors
Zilli, Thomas; Scorsetti, Marta; Zwahlen, Daniel; Franzese, Ciro; Förster, Robert; Giaj-Levra, Niccolò; Koustouvelis, Nikolaos; Bertaut, Aurelie; Zimmermann, Michel; D’Agostino, Giuseppe Roberto; Alongi, Filippo; Guckenberger, Matthias; Miralbell, Raymond; Förster, Robert; Giaj-Levra, Niccolò; D'Agostino, Giuseppe Roberto; Koutsouvelis, Nikolaos
- Abstract
<bold>Background: </bold>Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with localized prostate cancer. Promising results in terms of disease control and toxicity have been reported with 4 to 5 SBRT fractions. However, question of how far can the number of fractions with SBRT be reduced is a challenging research matter. As already explored by some authors in the context of brachytherapy, monotherapy appears to be feasible with an acceptable toxicity profile and a promising outcome. The aim of this multicenter phase I/II prospective trialis to demonstrate early evidence of safety and efficacy of a single-fraction SBRT approach for the treatment of localized disease.<bold>Methods: </bold>Patients with low- and intermediate-risk localized prostate cancer without significant tumor in the transitional zone will be treated with a single SBRT fraction of 19 Gy to the whole prostate gland with urethra-sparing (17 Gy). Intrafractional motion will be monitored with intraprostatic electromagnetic transponders. The primary endpoint of the phase I part of the study will be safety as assessed by CTCAE 4.03 grading scale, while biochemical relapse-free survival will be the endpoint for the phase II. The secondary endpoints include acute and late toxicity, quality of life, progression-free survival, and prostate-cancer specific survival.<bold>Discussion: </bold>This is the first multicenter phase I/II trial assessing the efficacy and safety of a single-dose SBRT treatment for patients with localized prostate cancer. If positive, results of ONE SHOT may help to design subsequent phase III trials exploring the role of SBRT monotherapy in the exclusive radiotherapy treatment of localized disease.<bold>Trial Registration: </bold>Clinicaltrials.gov identifier: NCT03294889 ; Registered 27 September 2017.
- Subjects
STEREOTACTIC radiotherapy; RADIOISOTOPE brachytherapy; TREATMENT effectiveness; PROSTATE cancer treatment; ONCOLOGY
- Publication
Radiation Oncology, 2018, Vol 13, Issue 1, pN.PAG
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-018-1112-0