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- Title
Increased Stimulatory Capacity of Spleen Cells from Adult Thymectomized Mice in Mixed Lymphocyte Reactions.
- Authors
Viallat, J. R.; Carnaud, C.; Bach, J. F.
- Abstract
The mechanism of T-cell tolerance to a thymus-dependent antigen was examined, using the adjuvant polyadenylic-polyuridylic acid (poly A:U). In adoptive transfer experiments, thymus cells obtained from donor mice 2 days after treatment with a tolerogenic dose of bovine γ-globulin (sBGG) did not cooperate with bone marrow (BM) cells in irradiated recipients challenged with aggregated BGG (aBGG). In contrast, thymus cells from donors given sBGG plus poly A:U retained their helper activity, as assayed by hemagglutination and rosette formation of spleen cells. The effect of poly A:U in preventing tolerance induction was also demonstrable in the cortisone-resistant population, in that thymus cells from cortisone-treated donors that had received sBGG and poly A:U retained their helper function. The presence of suppressor cells and the effect of poly A:U on their stimulation were also examined. sBGG-treated thymus cells suppressed the response of BGG-primed spleen cells in lethally irradiated mice, whereas thymus cells from donors treated with sBGG and poly A:U were not suppressive. These observations show that poly A:U prevents tolerance induction and the development of suppressor activity in T cells.
- Subjects
ADENOSINE monophosphate; THYMUS; IMMUNE response; LABORATORY mice; ANIMAL models of immunological tolerance; GLOBULINS; SUPPRESSOR cells; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 12, p1217
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00360.x