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- Title
Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapy.
- Authors
Dickinson, Michael; Hoyt, Rosemary; Roberts, Andrew W.; Grigg, Andrew; Seymour, John F.; Prince, H. Miles; Szer, Jeff; Ritchie, David
- Abstract
The utility of [18F]fluoro-2-deoxy-d-glucose positron-emission tomography (FDG-PET) for predicting outcome after autologous stem cell transplantation (ASCT) for diffuse large B cell lymphoma (DLBCL) is uncertain – existing studies include a range of histological subtypes or have a limited duration of follow-up. Thirty-nine patients with primary-refractory or relapsed DLBCL with pre-ASCT PET scans were analysed. The median follow-up was 3 years. The 3-year progression-free survival (PFS) for patients with positive PET scans pre-ASCT was 35% vs. 81% for those who had negative PET scans ( P = 0·003). The overall survival (OS) in these groups was 39% and 81% ( P = 0·01), respectively. In a multivariate analysis, PET result, number of salvage cycles and the presence of relapsed or refractory disease were shown to predict a longer PFS; PET negativity ( P = 0·04) was predictive of a longer OS. PET is useful for defining those with an excellent prognosis post-ASCT. Although those with positive scans can still be salvaged with current treatments, PET may useful for selecting patients eligible for novel consolidation strategies after salvage therapies.
- Subjects
LYMPHOMAS; B cells; DRUG therapy; STEM cells; POSITRON emission tomography
- Publication
British Journal of Haematology, 2010, Vol 150, Issue 1, p39
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2010.08162.x