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- Title
Clinicopathological and prognostic characteristics of CD56-negative multiple myeloma.
- Authors
Sahara, Naohi; Takeshita, Akihiro; Shigeno, Kazuyuki; Fujisawa, Shinya; Takeshita, Kaori; Naito, Kensuke; Ihara, Michio; Ono, Takaaki; Tamashima, Sadahiro; Nara, Kenji; Ohnishi, Kazunori; Ohno, Ryuzo
- Abstract
Summary. We analysed CD56 expression in 70 patients with multiple myeloma (MM) to determine its clinicopathological and prognostic significance. Fifty-five (79%) patients were CD56+ . CD56– patients (n = 15) had higher β2 microglobulin levels and a higher incidence of extramedullary disease, Bence Jones protein, renal insufficiency and thrombocytopenia than CD56+ patients. Their myelomas more frequently had a plasmablastic morphology. Overall survival was significantly lower in CD56– than CD56+ patients (22 vs 63 months, P = 0·0002). We conclude that CD56– MM is a discrete entity associated with more aggressive disease. The higher incidence of plasmablastic cases suggested that CD56– MM may develop from a less mature plasma cell than CD56+ MM.
- Subjects
MULTIPLE myeloma; PLASMA cells; PROGNOSIS
- Publication
British Journal of Haematology, 2002, Vol 117, Issue 4, p882
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03513.x